Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality
Identifieur interne : 001818 ( Main/Exploration ); précédent : 001817; suivant : 001819Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality
Auteurs : F. Goldblatt [Royaume-Uni] ; S. Chambers [Royaume-Uni] ; A. Rahman [Royaume-Uni] ; Da Isenberg [Royaume-Uni]Source :
- Lupus [ 0961-2033 ] ; 2009-07.
English descriptors
- Teeft :
- Active disease, Arthritis nephritis, Aureus, Azathioprine, Azathioprine pred, Bilag, British patients, Capd pred, Case notes, Cohort, Consecutive patients, Database information, Disease activity, Disease duration, Erythematosus, Esrd, General practitioner, Goldblatt, High dose prednisolone, Hospitalisation, Hospitalised, Immunosuppressant, Infection, Infectious diseases, Infective, Infective episode, Infective episodes, Lupus, Mycophenolate mofetil, Nephritis, Other causes, Pneumonia, Pred, Prednisolone, Range years, Renal disease, Rheumatol, Rheumatology, Risk factors, Sclerosing peritonitis, Septicaemia, Serious infection, Serious infections, Significant difference, Staphylococcus aureus, Systemic, Systemic lupus, Systemic lupus erythematosus, Whole cohort.
Abstract
This retrospective study determined the prevalence and nature of hospitalisations secondary to infection, and examined the mortality from infection in our large British cohort of patients with systemic lupus erythematosus (SLE). Casenote and database information of 104 consecutive patients attending the UCLH specialised SLE clinic were reviewed for the number of hospitalisations due to infection and the clinical and serological features of affected patients. Cohort mortality data were examined to identify deaths secondary to infectious diseases. Infection serious enough to result in hospitalisation occurred in 15% of the patients in the selected sample of our whole cohort. Six patients had more than one admission due to infection, with pneumonia being the most frequent. Typical bacterial pathogens were most commonly identified. A significant association between admissions for infection and nephritis (P < 0.05 by Chi-square) was identified; however, the use of high dose prednisolone or other immunosuppressants did not increase the risk for infection requiring hospitalisation (P > 0.5 by Chi-square) in our study. Between 1978 and 2007, 17 of 67 (25%) deaths in our SLE cohort of 470 patients were because of infection. Patients who died from infectious causes were more likely to have existing or previous renal disease than those who died from non-infectious causes (P < 0.01 by Chi-square). The majority who died from infection were on high dose prednisolone plus at least one other immunosuppressive agent and had serologically active disease. The study highlights the significant problem of infection in British patients with SLE. Early recognition and treatment of infectious diseases in these patients together with considered use of immunosuppressant medications and vaccinations may help to reduce the impact of these complications.
Url:
DOI: 10.1177/0961203308101019
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001D87
- to stream Istex, to step Curation: 001D87
- to stream Istex, to step Checkpoint: 000743
- to stream Main, to step Merge: 001822
- to stream Main, to step Curation: 001818
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality</title><author wicri:is="90%"><name sortKey="Goldblatt, F" sort="Goldblatt, F" uniqKey="Goldblatt F" first="F" last="Goldblatt">F. Goldblatt</name></author><author wicri:is="90%"><name sortKey="Chambers, S" sort="Chambers, S" uniqKey="Chambers S" first="S" last="Chambers">S. Chambers</name></author><author wicri:is="90%"><name sortKey="Rahman, A" sort="Rahman, A" uniqKey="Rahman A" first="A" last="Rahman">A. Rahman</name></author><author wicri:is="90%"><name sortKey="Isenberg, Da" sort="Isenberg, Da" uniqKey="Isenberg D" first="Da" last="Isenberg">Da Isenberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5DB7653A9CCA66E47155A69A3CBC8B82D29DEC6F</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1177/0961203308101019</idno><idno type="url">https://api.istex.fr/ark:/67375/M70-XG9M9NNG-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001D87</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D87</idno><idno type="wicri:Area/Istex/Curation">001D87</idno><idno type="wicri:Area/Istex/Checkpoint">000743</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000743</idno><idno type="wicri:doubleKey">0961-2033:2009:Goldblatt F:serious:infections:in</idno><idno type="wicri:Area/Main/Merge">001822</idno><idno type="wicri:Area/Main/Curation">001818</idno><idno type="wicri:Area/Main/Exploration">001818</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality</title><author wicri:is="90%"><name sortKey="Goldblatt, F" sort="Goldblatt, F" uniqKey="Goldblatt F" first="F" last="Goldblatt">F. Goldblatt</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Rheumatology, Department of Medicine, University College London Hospital</wicri:regionArea><wicri:noRegion>University College London Hospital</wicri:noRegion></affiliation><affiliation></affiliation></author><author wicri:is="90%"><name sortKey="Chambers, S" sort="Chambers, S" uniqKey="Chambers S" first="S" last="Chambers">S. Chambers</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Rheumatology, Department of Medicine, University College London Hospital</wicri:regionArea><wicri:noRegion>University College London Hospital</wicri:noRegion></affiliation></author><author wicri:is="90%"><name sortKey="Rahman, A" sort="Rahman, A" uniqKey="Rahman A" first="A" last="Rahman">A. Rahman</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Rheumatology, Department of Medicine, University College London Hospital</wicri:regionArea><wicri:noRegion>University College London Hospital</wicri:noRegion></affiliation></author><author wicri:is="90%"><name sortKey="Isenberg, Da" sort="Isenberg, Da" uniqKey="Isenberg D" first="Da" last="Isenberg">Da Isenberg</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Rheumatology, Department of Medicine, University College London Hospital</wicri:regionArea><wicri:noRegion>University College London Hospital</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Lupus</title><idno type="ISSN">0961-2033</idno><idno type="eISSN">1477-0962</idno><imprint><publisher>SAGE Publications</publisher><pubPlace>Sage UK: London, England</pubPlace><date type="published" when="2009-07">2009-07</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="682">682</biblScope><biblScope unit="page" to="689">689</biblScope></imprint><idno type="ISSN">0961-2033</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0961-2033</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active disease</term><term>Arthritis nephritis</term><term>Aureus</term><term>Azathioprine</term><term>Azathioprine pred</term><term>Bilag</term><term>British patients</term><term>Capd pred</term><term>Case notes</term><term>Cohort</term><term>Consecutive patients</term><term>Database information</term><term>Disease activity</term><term>Disease duration</term><term>Erythematosus</term><term>Esrd</term><term>General practitioner</term><term>Goldblatt</term><term>High dose prednisolone</term><term>Hospitalisation</term><term>Hospitalised</term><term>Immunosuppressant</term><term>Infection</term><term>Infectious diseases</term><term>Infective</term><term>Infective episode</term><term>Infective episodes</term><term>Lupus</term><term>Mycophenolate mofetil</term><term>Nephritis</term><term>Other causes</term><term>Pneumonia</term><term>Pred</term><term>Prednisolone</term><term>Range years</term><term>Renal disease</term><term>Rheumatol</term><term>Rheumatology</term><term>Risk factors</term><term>Sclerosing peritonitis</term><term>Septicaemia</term><term>Serious infection</term><term>Serious infections</term><term>Significant difference</term><term>Staphylococcus aureus</term><term>Systemic</term><term>Systemic lupus</term><term>Systemic lupus erythematosus</term><term>Whole cohort</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This retrospective study determined the prevalence and nature of hospitalisations secondary to infection, and examined the mortality from infection in our large British cohort of patients with systemic lupus erythematosus (SLE). Casenote and database information of 104 consecutive patients attending the UCLH specialised SLE clinic were reviewed for the number of hospitalisations due to infection and the clinical and serological features of affected patients. Cohort mortality data were examined to identify deaths secondary to infectious diseases. Infection serious enough to result in hospitalisation occurred in 15% of the patients in the selected sample of our whole cohort. Six patients had more than one admission due to infection, with pneumonia being the most frequent. Typical bacterial pathogens were most commonly identified. A significant association between admissions for infection and nephritis (P < 0.05 by Chi-square) was identified; however, the use of high dose prednisolone or other immunosuppressants did not increase the risk for infection requiring hospitalisation (P > 0.5 by Chi-square) in our study. Between 1978 and 2007, 17 of 67 (25%) deaths in our SLE cohort of 470 patients were because of infection. Patients who died from infectious causes were more likely to have existing or previous renal disease than those who died from non-infectious causes (P < 0.01 by Chi-square). The majority who died from infection were on high dose prednisolone plus at least one other immunosuppressive agent and had serologically active disease. The study highlights the significant problem of infection in British patients with SLE. Early recognition and treatment of infectious diseases in these patients together with considered use of immunosuppressant medications and vaccinations may help to reduce the impact of these complications.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Goldblatt, F" sort="Goldblatt, F" uniqKey="Goldblatt F" first="F" last="Goldblatt">F. Goldblatt</name></noRegion><name sortKey="Chambers, S" sort="Chambers, S" uniqKey="Chambers S" first="S" last="Chambers">S. Chambers</name><name sortKey="Isenberg, Da" sort="Isenberg, Da" uniqKey="Isenberg D" first="Da" last="Isenberg">Da Isenberg</name><name sortKey="Rahman, A" sort="Rahman, A" uniqKey="Rahman A" first="A" last="Rahman">A. Rahman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001818 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001818 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5DB7653A9CCA66E47155A69A3CBC8B82D29DEC6F
|texte= Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality
}}
| This area was generated with Dilib version V0.6.33. |  |